ABSTRACT

Pollutant damage to the physiology of the peripheral vessels and heart is widespread and must be dealt with in order to ensure good myocardial and vascular function.

Vascular perfusion generated from the heart pump and peripheral resistance is the most important physiological function of the vascular tree. Perfusion is signicant because it delivers oxygen and other nutrients both directly and indirectly to all cells and because it removes waste. Oxygen is essential for both the normal electrical activity and pumping efciency. The amount of oxygen that vascular perfusion delivers to an area determines both tissue function and dysfunction. As long as there is a balance between pumping and vascular resistance, good homeostasis occurs with no arrhythmias or heart failure. Chemical sensitivity does not exacerbate the imbalance initially, but as the chemical sensitivity progresses, the heart and peripheral vascular involvement increases the sensitivity.