ABSTRACT
Thrombophilia is an abnormality of haemostasis predisposing to thrombosis. It may be:
Hereditary:
Activated protein C resistance (associated with factor V Leiden mutation)
Protein C deficiency
Protein S deficiency
Antithrombin deficiency
Prothrombin gene mutation
Acquired:
Antiphospholipid syndrome
Acquired activated protein C resistance
Polycythaemia
Other conditions (e.g. malignancy)
Hyperhomocysteinaemia is a thrombophilia with genetic and acquired origins.