ABSTRACT
The purposes of this chapter are (i) to review the mathematical models used to predict the deposition of inhaled aerosol particles in the human respiratory tract, (ii) to consider how appropriate it is to use these models for therapeutic aerosol deposition, and (iii) to propose what features may need to be incorporated into future deposition models to allow for their use in predicting therapeutic aerosol deposition. The calculation of particle removal is a function not only of particle size but also of the breathing characteristics and the shape of the respiratory airways, as discussed in the previous chapter.
