ABSTRACT
Ovulation induction is the process of promotion of follicular growth and development culminating in ovulation. Introduction of gonadotrophins, followed by antiestrogens has revolutionized the practice of reproductive endocrinology. Introduction of clomiphene citrate in the 1960s has been a major therapeutic breakthrough.1 This brought into reality the novel notion of chemical initiation of ovulation with a synthetic compound as opposed to hormonal ovulation induction by a naturally occurring hormone.2 This was followed by synthesis and clinical use of other compounds of the same family. The most widely used of these antiestrogens is tamoxifen citrate (ICI 46, 474). Being in clinical use since 1970s, it now has a firm place as an adjuvant in the management of breast cancer and prevention of its recurrence in the contralateral breast. This has largely overshadowed its efficacy as an ovulation inducing agent.
