ABSTRACT
Recent advancements in brain drug delivery have revolutionized the field of neuroscience and opened new avenues for the treatment of neurological disorders. Overcoming the blood–brain barrier (BBB) has been a significant challenge, but innovative techniques and technologies have emerged to enhance drug delivery to the brain. Nanoparticles and nanocarriers have been engineered to encapsulate drugs and transport them across the BBB, while ultrasound-assisted drug delivery using microbubbles has shown promise in inducing transient disruptions of the BBB. Neurosurgical implants have provided a means for localized drug delivery and continuous monitoring, while gene therapy approaches have allowed for targeted treatment of genetic-based neurological disorders. Brain-machine interfaces have emerged as cutting-edge technologies, enabling direct communication between the brain and external devices for drug delivery and other therapeutic interventions. These recent advancements offer great potential for improving the efficacy and precision of brain drug delivery, ultimately leading to enhanced treatment outcomes for patients with neurological disorders.
