ABSTRACT
Chromosome aneuploidy is common in human gametes and pre-implantation embryos and is a major cause of pregnancy failure, miscarriage, and still births, with an incidence at birth of <0.3%. Most aneuploidies originate in the oocyte through errors in maternal meiosis and these increase exponentially in women in their late 30s and early 40s. Five early RCTs demonstrated improved clinical outcomes using different technologies and in various groups of patients with PGT-A. Rubio et al. sought to evaluate the effect of PGT-A in an older population with higher baseline rates of aneuploidy. Aneuploidy was detected in 102 embryos, leading to 41 (40.2%) positive pregnancy tests, 24 (23.5%) clinical pregnancies, and no sustained implantations beyond 13 weeks' gestation, for a 100% negative predictive value of aneuploid embryos. Also, the number and type of aneuploidies present also affected the outcomes.
