ABSTRACT
"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health
Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development.
Features:
- Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies
- Lessons-learned from successful Precision Medicine case studies
- A variety of exciting and emerging biomarker technologies
- The next frontiers and future challenges of biomarkers in Precision Medicine
Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.
TABLE OF CONTENTS
part 1|1 pages
What Is a Biomarker and Its Role in Drug Development?
chapter 1.2|11 pages
In Search of Predictive Biomarkers in Cancer Immunotherapy
part 2|1 pages
Biomarkers in Preclinical Sciences
chapter 2.1|8 pages
Lost in Translation
chapter 2.3|10 pages
The DIAMONDS Platform
part 3|1 pages
Biomarkers in Translational Medicine
chapter 3.1|9 pages
Lost in Translation
part 4|1 pages
Biomarker-Informed Clinical Trials
part 5|1 pages
The Road Ahead
chapter 5.3|9 pages
Ectopic Gene Deregulations and Chromosome Conformations
chapter 5.7|8 pages
Computational Biology
part 6|1 pages
Lessons from the Past and Pioneers of the Future
chapter 6.4|14 pages
Delivering Companion Diagnostics for Complex Biomarkers
chapter 6.5|7 pages
Delivering the Personalized Medicine Promise
chapter 6.6|8 pages
Development, Launch, and Adoption of a Pharmacodiagnostic
chapter 6.7|7 pages
Biomarker Consortia to Drive BM Discovery and Clinical Applications in the UK
part 7|1 pages
Paving a New Era of Personalized Medicine
chapter 7.1|8 pages
A New Era of Personalized Medicine
chapter 7.12|6 pages
Mass Spectrometry Imaging
chapter 7.13|7 pages
Insights of Personalized Medicine from the Gut Microbiome
part 8|1 pages
The Next Frontiers of Therapeutic Target Areas
chapter 8.4|13 pages
Advances in Cardiovascular Diagnostics
chapter 8.6|9 pages
Progressing Towards Precision Psychiatry
part 9|1 pages
Lessons Learned