ABSTRACT

Idiopathic Parkinson’s disease (IPD) represents the most common cause of Parkinsonism,1 the extrapyramidal movement disturbance that manifests as some combination of bradykinesia, rigidity, and resting tremor. However, many less-common causes of Parkinsonism are recognized, and clinical misclassification is not uncommon.2 As a result, postmortem examination of the brain is required for confirmation of diagnoses. In this chapter, the neuropathology of IPD and a number of other disorders manifesting as Parkinsonism are discussed.