ABSTRACT

Solution Conformation on Binding to (1→3)-β-D-Glucan Receptors .........16 1.7 Glucan Receptors Differentially Recognize Glucan Polymers

Based on Solution Conformation and Molecular Weight .............................17 1.8 Identification of Dectin-1 and Scavenger Receptors as Glucan-Specific

Membrane Receptors .....................................................................................20 1.8.1 The Role of Dectin-1 as a Primary Glucan Receptor.......................20 1.8.2 Scavenger Receptors as Glucan Binding Sites..................................21

1.9 Activation of Proinflammatory and Immunoregulatory Intracellular Signaling Pathways by Glucans ....................................................................22 1.9.1 Toll-Like Receptor 2 Recognition and Signaling in Response to